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doi: 10.1007/s40618-024-02459-3

The addition of GLP-1 RAs to insulin therapy may allow for improved glycaemic control and, in selected cases, potential de-escalation or discontinuation of insulin

Previous results indicate that TNC is downregulated by GLP-1RA treatment and correlates with incident CVD 43 , suggesting that TNC may act as a mediator, with downregulation contributing to the cardiovascular-protective effects of GLP-1RAs